Which Hormonal Deficiency Causes Diabetes Insipidus?
Diabetes insipidus can cause problems with your pituitary gland or kidneys. Usually, the body maintains a balance between fluids and urine produced.
Kidneys remove excess fluid by making urine, which is temporarily stored in your bladder.
When fluid is processed, the pituitary gland shows the kidneys to retain fluid and make less urine. Antidiuretic hormone (vasopressin) and deficiency of this hormone cause diabetes insipidus.
It is created in the hypothalamus and provides in the pituitary gland.
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Table of Contents
Causes and types of diabetes insipidus
The forms of diabetes insipidus are:
Neurogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus
Psychogenic Diabetes Insipidus
Gestational Diabetes Insipidus
Neurogenic Diabetes Insipidus
Neurogenic or central diabetes insipidus is an inadequate response of ADH, which occurs when an organic lesion of the hypothalamus, posterior pituitary partially or entirely block ADH synthesis, transport, or release.
The causes are:
Damage to the hypothalamus or pituitary gland
Cranial surgery
Hypothalamic or pituitary tumors
Aneurysm
Thrombosis
Infection, inflammation
Head injury
Skull fracture
Immunologic disorders
In some cases, the cause is unknown.
Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus occurs when there is any problem in the renal tubules.
The structures in kidneys that cause water to eject or reabsorbed.
This defect makes kidneys unable to respond to ADH appropriately.
The defects may be due to a genetic disorder or a chronic kidney disorder.
An inadequate renal response to ADH causes it.
Kidney disorder
Pyelonephritis
Destructive uropathies
Polycystic disease
Intrinsic renal disease
Certain drugs such as lithium, tetracycline, general anesthetic such as methoxyflurane.
Demeclocycline also can cause nephrogenic diabetes insipidus.
Psychogenic diabetes insipidus
Psychogenic diabetes insipidus is because by an extreme large fluid intake, which may be idiopathic or related to psychosis.
In this form of diabetes insipidus, excessive fluid intake leads to suppression of ADH
The polydipsia and resultant polyuria washout ADH more quickly than it.
Drinking too much liquid can result from abnormal Thirst caused by damage to the thirst-regulating mechanism situated in the hypothalamus.
Gestational diabetes insipidus
Gestational diabetes insipidus occurs only in pregnancy and when an enzyme made by the placenta destroys the ADH in the mother.
Which hormonal deficiency causes diabetes insipidus?
Diabetes insipidus can cause problems with your pituitary gland or kidneys. Usually, the body maintains a balance between fluids and urine produced.
Kidneys remove excess fluid by making urine, which is temporarily stored in your bladder.
When fluid is processed, the pituitary gland shows the kidneys to retain fluid and make less urine. Antidiuretic hormone (vasopressin) and deficiency of this hormone cause diabetes insipidus.
It is created in the hypothalamus and provides in the pituitary gland.
Diagnosis of diabetes insipidus
Urinary concentration
Plasma concentration
Level of ADH in blood
Urine output
MRI of head
Blood investigation
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The treatment of diabetes insipidus depends on what form of the condition patient has.
Central diabetes insipidus
The cause of this form of diabetes insipidus is a lack of ADH.
Patients with desmopressin as a nasal spray, as an oral tablet, or injection patient may need only to increase water intake About 2.5 litters in a day.
Nephrogenic diabetes insipidus
This condition is due to kidneys not correctly responding to ADH so, and Low salt diet help reduce the number of urine kidneys make And also need to drink enough water to avoid dehydration.
Drugs used to treat nephrogenic diabetes include anti-inflammatory medication and diuretics
Psychogenic diabetes insipidus
By mental illness, treating the mental illness may relieve psychogenic diabetes insipidus.
Gestational Diabetes Insipidus
Treatment of this form of DI is synthetic hormone desmopressin.
In rare cases, this form of the condition is caused by an abnormality in the thirst mechanism.
In these rare cases, doctors don’t prescribe desmopressin.
Complication of diabetes inipidus
Shunting of growth
Gangrene
Cataract
Coma
Nephropathy
Neuropathy
Conclusion
Diabetes Insipidus: Depending on the underlying cause. A deficiency of hormones can cause it.
When treated correctly, the condition usually does not become severe or a problem for years.
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