Huntington’s disease is a chronic, genetic, progressive, neurodegenerative disorder characterized by involuntary muscle movements, deterioration of cognitive processes and memory (dementia).
It is caused by degeneration of the cerebral cortex and basal ganglia.
Caused by a single defective gene on chromosome 4. This leads to nerve cell damage in the brain’s areas, including the basal ganglia and cerebral cortex.
This leads to the gradual onset of physical, mental, and emotional changes.
Transmitted as an autosomal dominant genetic disorder.
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Huntington’s disorder is an inherited neurodegenerative disorder in which brain cells are damaged and die over time, beginning to progressive loss of mental and physical abilities.
Inheritance is also known as autosomal domaint. A person has pair of the gene, but one abnormal copy is enough to cause the disease. Children of an affected parent have a 45 to 50% chance of inheriting the gene’s abnormal copy, hence the disease.
Life expectancy is generally around 10 to 20 years of visible symptoms. Most life-threatening complications result from muscle coordination with pulmonary aspiration, increasing pneumonia, being the most common cause of death in patients.
Initially, the treatment process starts with tests like brain imaging and computerized tomography (CT) scans. It helps us provide detailed pictures of brain structures and show which parts of the brain are affected by the disease. The test is also used to rule out other conditions that are associated with you.
One of the most critical procedures in the treatment of Huntington’s disease is genetic counseling.
There is a fifty-fifty chance to improve the condition with medicines as there are common side effects that may make the patient more suicidal.
Some medicines are used to suppress the involuntary movements that you experience and help improve your cognitive powers and help you have control over your body.
There is no cure treatment focused on minimizing symptoms.
Antipsychotic drugs, such as haloperidol (Haldol) and chlorpromazine, have side effects of suppressing movements.
Antidepressant for emotional disturbances
Anti parkinsonism such as levodopa for muscle movement.
Huntington’s disorder is an incurable and fatal neurodegenerative disorder characterized by movement problems and various other symptoms. Intelligent scientists work around the clock to develop treatments for the cure of disorder.
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