What Are The Most powerful Anti Anxiety Drugs?

Anxiety is an extension of sorrow, feeling bad, lack of interest in daily activities, or lack of happiness. We are familiar with all these things, but when all these symptoms persist for a long time in a person’s life and start to affect that person very much, then you call it anxiety.

Drugs that are used to reduce the symptoms of anxiety are called anti-anxiolytic drugs.

Anti Anxiety Drugs

It is CNS depressants which control the symptom of anxiety.

They produce a calming effect on anxiety states without interfering with normal mental or physical functions.

And now we about most powerful anti anxiety drugs.

anti anxiety drugs
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Table of Contents

Indications of anti anxiety drugs

  • Obsessive-compulsive 
  • Post-traumatic stress 
  • Bipolar I disorder
  • Other psychiatric indication includes alcohol withdrawal, substance-induced, and psychotic agitation.
  • Generalized anxiety disorder, adjustment disorder with anxious mood.
  • Panic disorder, agoraphobia, and school phobia (particularly alprazolam and clonazepam)
  • Depression 
  • Insomnia
  • Stage 4 N REM sleep disorders like enuresis, somnambulism, (Diazepam reduces the duration of stage 4 N REM sleep).
  • Nightmares (Diazepam also reduces REM sleep duration) 
  • Anesthesia 
  • To produce skeletal muscle relaxation (e.g., in tetanus, cerebral palsy)  
  • For anticonvulsant use
  • Treatment of alcohol and other drug withdrawal syndromes. 
  • For minor surgical, endoscopic, or obstetric procedures. 
  • Mania 
  • Antipsychotic induced akathisia 
  • Emergency management of acute psychoses ( iv lorazepam, along with parenteral antipsychotics) 
  • Narcoanalysis or abreaction (IV diazepam) 
  • Treatment-resistant schizophrenia (experimental use in High doses)
  • Psychosomatic disorders 

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Most powerful anti anxiety drugs


  • Phenobarbital
  • Secobarbital
  • Thiopentone

Non – Barbiturates, Non-Benzodiazepine Antianxiety

  • Meprobamate glutethimide, ethanol, diphenhydramine, and methaqualone.


  • Buspirone, Gepirone


  • It is a choice of treatment
  • Short-acting – oxazepam, lorazepam, alprazolam
  • Very short-acting- Triazolam, midazolam
  • Long-acting – chlordiazepoxide, Diazepam (valium, closed), lorazepam
  • Antianxiety drugs depress subcortical levels of
  • the CNS, particularly the limbic system and reticular formation. They may potentiate the effects of the powerful inhibitory neurotransmitter GABA in the brain, thereby
  • Producing a calmative effect.

Side effect of anti anxiety drugs

  • Sedation
  • Light headedness
  • Cognitive impairment
  • Vertigo sometimes
  • Confusional state in elderly
  • Increased appetite
  • Weight gain
  • Alteration in sexual function 
  • Rashes are uncommon
  • Some women fail to ovulate when on regular use of BZDs
  • Dependency on others

Different Drugs related to Mental Health that you might be interested in:

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