How Long Does Prednisone Weaken The Immune System?

If you are currently being used or have recently been treated with prednisone, you should let your doctor know before taking the SARS-CoV-2 (Covid-19) mRNA-1273 vaccine.

Depending on the dose and time you have been on prednisone, you may have a decreased response to the vaccine.

In some conditions, your doctor may want to delay vaccination to give your body time to recover from the effects of the prednisone drug.

If you have recently been vaccinated with the SARS-CoV-2 covid-19 mRNA-1273 vaccine, your doctor may take to postpone treatment with prednisone for a few weeks or more.

Tell your doctor about other medicines you use, vitamins, and herbs. However, do not stop using any medicines without first talking to your doctor.

I had earlier shared  Vaccines Covid 19 | Is Covid 19 Vaccine Safe? I hope you read this post

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Prednisone and covid

A common side effect of prednisone is the increased risk of infections. Therefore, it is essential to understand right now in light of the current Covid-19 crisis.

Prednisone a that’s used by many people with inflammatory arthritis, chronic pain, asthma, and a variety of other diseases — has some significant pluses and minuses.

Nevertheless, it is effectively relieved of pain and inflammation.

Unfortunately, taking more than your suggested dose can have severe downsides; even taking a doctor-approved dose for an extended period can be problematic. 

Prednisone has a laundry list of possible side effects, including 

  • High blood sugar
  • High blood pressure

To learn more about : Covid Vaccine and High Blood Pressure

  • Glaucoma
  • Sleep issues

Read: Do I Have A Sleep Disorder?

  • Memory, mood 
  • Weight gain 
  • Swelling
  • Fluid retention

 Side effects tend to increase with high doses and a longer time of use.

Another side effect of prednisone is the increased risk of infections bacterial, fungal, and viral. 

A May 2020 editorial in the research cautioned that people who always take oral steroids should be considered high risk for covid 19 and may be more prone to developing complications.

Additionally, preliminary data presented at the American research study that people on moderate or higher doses of steroids who improved Covid-19 were more likely to develop severe symptoms than those not using these drugs.

Suggested read: Steroid Cream For Phimosis | How To Get Rid Of Phimosis?

How long does prednisone weaken the immune system?

A new study, Gastroenterology, found that inflammatory bowel disease ulcerative colitis and people living with Crohn’s who use steroid medicine are more apt to develop the risk of Covid-19 than those who don’t use these drugs.

Prednisone lowers inflammation during the entire body, which homes in particular types of inflammatory molecules that are over-expressed in people with chronic autoimmune diseases.

It does that by imitating the prednisone that is naturally produced by the adrenal glands.  When you put a synthetic like prednisone into your body, your adrenal glands stop producing their supply. 

The resulting lower level of inflammation during your body helps relieve signs in joints or other trouble spots. But it may also end up your immune system function.

Good data shows that prednisone makes you more susceptible to various infections, maybe even more so than biologics and methotrexate.

Prednisone will kill off lymphocytes, a type of white blood cell, at high enough doses, such as those sometimes used in chemotherapy. 

Prednisone dose-dependent and 5 mg are different than 40 mg,” says a research rheumatologist You’re going to have far and impairment if you’re taking over dosage.”

The method of delivery or the way you take — prednisone matters too.

For example, people who use corticosteroids systemically have a higher risk of developing immune system side effects than those who use the drug topically or through an inhaler or nasal spray for respiratory infection.

The more your immune system is, the higher your risk of contracting a contagious infection and covid.

However, more study is needed on how taking corticosteroids specifically affects higher risks related to covid-19.

I also wrote a article: How Can I Boost My Immune System? 


Advice for People Taking prednisone

Do not stop taking your commonly use medicines without advice from a doctor.

American research on treating patients during the covid pandemic suggests using the “lowest powerful dose of corticosteroids to control underlying rheumatic condition.

Suppose your health is good at the moment. In that case, meaning, the situation for which you’re taking prednisone seems well-controlled — your doctor might talk with you about the idea of starting to wean off prednisone, especially if you’re taking a higher dosage.

You and your doctor should work together to see whether you should remain on your regular prednisone dosage or attempt to taper it down.

It is usually not recommended for long-time use anyway. However, the additional threat of Covid-19 might be an excellent reason to consider slowly stopping it.

People on a simple prednisone dose, possibly 5 mg, should not be worried about the drug putting  them at increased risk. When in doubt, always advise your doctor

Do Not Stop prednisone

Your doctor decides that you no higher need corticosteroids; could you not attempt to stop them?

In addition to risking a flare of the situation you were using your steroids to treat, such a drastic change could throw your body into an adrenal crisis, which can be fatal.

Therefore, steroids must always be tapered rather than ended when you stop using them.

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